For instance, circ-ABCC1 in CD133+cell extracted from CRC cells upregulated the expression of β-catenin in the nucleus and inhibited the expression of β-catenin in the cytoplasm by binding with β-catenin, which activating the wnt pathway, then mediated CRC cell stemness and metastasis 36. Here, PROM1 is linked to colorectal carcinoma.