Some reports also indicated that exosomal circRNAs were closely related to the immunosuppression in TME: The study from Yang et al. indicated that exosomal circPSMA1 functioned as a tumor promoter through the circPSMA1/miR-637/Akt1-β-catenin (cyclin D1) regulatory axis, which can facilitate the immunosuppression of triple-negative breast cancer 101. The gene discussed is AKT1; the disease is neoplasm.