Proinflammatory factors produced from a chronic inflammatory state, such as MCP-1, may promote the development of T2DM by increasing insulin resistance in peripheral tissues like the liver, muscle, and adipose tissue (Hotamisligil, 2017), and anti-inflammatory treatment had beneficial effects on glucose metabolism and cardiovascular complications of diabetes (Donath, 2014). This evidence concerns the gene CCL2 and type 2 diabetes mellitus.