Janelidze et al. (2017) reported a higher Qalb in individuals with T2DM compared with subjects without T2DM in two different cohorts with a total of 1,015 subjects, and the authors demonstrated that T2DM was associated with high CSF levels of intercellular adhesion molecule-1 (p < 0.001), vascular cellular adhesion molecule-1 (p = 0.007), and vascular endothelial-derived growth factor (p = 0.024), CSF biomarkers of angiogenesis and endothelial dysfunction. This evidence concerns the gene ICAM1 and type 2 diabetes mellitus.