The analysis of top keywords using burst detection (Figure 8B) indicated that in the last two decades aberrant crypt focibifidobacterium (Ridlon et al., 2016; Routy et al., 2018), beta-glucuronidase lactic acid bacteria 16 s ribosomal RNA microflora toll-like receptor (Koropatkin et al., 2012), Crohn’s disease and butyrate-producing bacteria have attracted much attention from the researchers in this field (Farrell and Peppercorn, 2002). Here, GUSB is linked to Crohn disease.