TLR4 and neoplasm: These genes included those related to P/DAMP signaling (e.g., Il6, Tlr1, Tlr4, Il1b, Il18), necroptotic tumor cell death (e.g., Casp1, Casp8, Il1b), and activation of the adaptive immune system (e.g., Cd80, Cd8a, Ccr5, Cxcl10).