These genes included those related to P/DAMP signaling (e.g., Il6, Tlr1, Tlr4, Il1b, Il18), necroptotic tumor cell death (e.g., Casp1, Casp8, Il1b), and activation of the adaptive immune system (e.g., Cd80, Cd8a, Ccr5, Cxcl10). This evidence concerns the gene CASP8 and neoplasm.