Of note, after adjustment for CEA and the interaction between IGF2 methylation and CEA, the effect of IGF2 hypermethylation itself on CRC prognosis remained statistically significant (HR, 0.44, 95% CI: 0.24-0.79; P=0.006), suggesting a robust and independent role for PBL IGF2 hypermethylation in predicting the prognosis of CRC. The gene discussed is CEACAM5; the disease is colorectal carcinoma.