The creation of lactate impairs the CTLs’ capacity to multiply and produce cytokines, which reduces their cytotoxic activity (23), suppresses the production of IFNγ by NK and NKT cells, and reduces their antitumor function (24, 25), mediates the differentiation of DCs (26), increases Treg activity (27), and recruits macrophages and induces their functional polarization into TAMs (28), leading to immunosuppression and promoting tumor cell growth and metastasis. Here, IFNG is linked to neoplasm.