Interestingly, IFNγ produced by immunotherapy-activated CD8 T cells suppresses the expression of SLC3A2 and SLC7A11, two components of the glutamate-cystine anti-transport protein system xc-, and prevents tumor cells from utilizing cystine, promoting lipid peroxidation and ferroptosis in tumor cells (53, 54). Here, CD8A is linked to neoplasm.