D3S2 was linked to TAT (a cell-penetrating peptide) to act on OC cells to enhance penetration, and Tat-D3S2 treatment reduced the induction of autophagy in OC cell lines, as evidenced by a decrease in LC3I/LC3II conversion rate (103).EP-100 is composed of a natural ligand for GnRH linked to cleavage peptide (CLIP-71), which delivers the cleaved peptide to GnRH receptor-positive cancer cells, thereby exerting selective toxic effects (104). The gene discussed is GNRH1; the disease is cancer.