More interestingly, Tf contributes to the targeting of T7 peptides to small cavities on the surface of TfR, which in turn translocate into the cell and increase its endocytosis rate (88).Wu and colleagues (63) reported that T7 peptide can enhance the uptake and penetration of A2780 with higher TFR expression levels to liposomes, thereby significantly enhancing the inhibitory effect of PTX on cells and 3D tumor spheroids. Here, TFRC is linked to neoplasm.