For example, several CAF subsets have been identified in PDAC via single-cell RNA sequencing, such as myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs) in TME, wherein myCAFs characterized by high α-SMA expression, contribute to secreting ECM proteins, tumor migration and resistance, whereas iCAFs secrete inflammatory factors, such as IL-6, IL-11 (138). This evidence concerns the gene IL6 and neoplasm.