These included a set of known and suspected proto-oncogenic drivers (e.g., FGR, RUNX1, STAT5A, MYO7B, TMEM26, and CRTAM) in T-ALL which lost H3K27ac peaks at the adjacent super-enhancers and were down-regulated (FDR ≤ 0.05) following RUNX1-KD (Figures 2D and 2E). This evidence concerns the gene CRTAM and acute lymphoblastic leukemia.