RUNX1 and acute lymphoblastic leukemia: ,58CDC25A is highly expressed in T-ALL (Figure 6D) and its expression was significantly (FDR ≤0.05) down-regulated (>2-fold) upon RUNX1-KD and with a concomitant loss of H3K4me3 (2.17-fold) and H3K27ac (1.65-fold) promoter density (Figures 6E and 6F).