Termed an “oncomicroprotein”, APPLE was shown to localize on the ribosome-bound ER and interact with translation elongation factors and poly(A)-binding proteins to promote mRNA looping and eIF4A complex assembly to regulate the translation of a subset of mRNAs that contribute to AML progression, thus supporting a pro-cancer translation program.145. The gene discussed is ASH1L-AS1; the disease is cancer.