Notably, KOAD mice had smaller YM-1(+) and Arg-1(+) areas than AD mice, while the percentage of YM-1(+) or Arg-1(+) microglia was similar between AD and KOAD mice (Figures 6I, J), suggesting that NP65 deficiency does not affect microglial production of YM-1 and Arg-1. The gene discussed is NPTN; the disease is Alzheimer disease.