TNF and Abnormal retinal morphology: Since cGMP might be related to apoptotic and non-apoptotic cell death, and one might be induced by the other or both could occur in parallel, we studied receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and poly (ADP-ribose) (PAR) (Supplementary Figure 3F): These regulate non-apoptotic cell death, and DNA damage and inflammation, respectively, in different forms of retinal diseases, and may be induced by TNF (Murakami et al., 2011, 2013; Humphries et al., 2015; Tao et al., 2022).