Dgcr8 haploinsufficient mice (Dgcr8 ±) displayed reduced expression of miRNAs in the brain and showed cognitive deficits, along with altered electrical properties of layer 5 pyramidal neurons in the mPFC, decreased complexity of basal dendrites, and reduced excitatory synaptic transmission (Schofield et al., 2011). This evidence concerns the gene DGCR8 and Cognitive impairment.