Recent evidences hypothesized a bidirectional link between an altered iron metabolism with parenchymal overload (hyperferritinemia due to alcohol-related intestinal hyper-absorption and haemolysis, markedly impaired hepcidin production due to persistent inflammation and reduced hepatic biosynthesis) and the severity of liver disease with possible haemolysis [27, 28]; in fact, spur cell haemolysis could be the culprit cause of iron overload found in several explanted livers after LT for alcoholic cirrhosis [29]. Here, HAMP is linked to Tangier disease.