Applying a distinctive signature of 537 deregulated genes in CIC‐rearranged sarcoma with RNA seq, Palmirini et al. in a recent paper showed that the CIC::DUX4 transcriptional profile compared that of ES was enriched in gene sets including DUSP4, ETV1/4, IGF2, and IGF2BPs, PTX 1 and 3 that are associated with activity of irinotecan, proteasome inhibitors (bortezomib and MG262), and histone deacetylase inhibitors (scriptaid and vorinostat).40 Here, DUX4 is linked to sarcoma.