NCOA2 is involved recurrently in gene fusions associated with soft tissue tumors that include angiofibroma of soft tissue (AHRR::NCOA2) and spindle cell/sclerosing rhabdomyosarcoma (TEAD1::NCOA2 and VGLL2::NCOA2) (17–19). This evidence concerns the gene NCOA2 and soft tissue neoplasm.