RUNX2 and sarcoma: Homozygous deletion of Runx3 exhibited growth suppression of wild-type mesenchymal chondrosarcoma cells but not Runx2-knockout cells in vitro (Figure 7B and Supplemental Figure 7), whereas growth property of sarcoma in vivo was not affected significantly by Runx3 knockout both in wild-type and Runx2-knockout sarcoma cells (Figure 7C).