Thus far, data on these processes in the context of placental biology are scarce, showing that the expression of CGI58 mRNA is increased by 2-fold in placentas from pregnancies complicated by gestational diabetes or maternal obesity, with no change in PNPLA2 in these conditions, and reduced by nearly 2-fold in placentas from women with preeclampsia (71–73). The gene discussed is PNPLA2; the disease is gestational diabetes.