Hence, the three PD related mutations (R1398H, R1441C and G2019S) affect the two enzymatic activities in very different ways when we compare fl-LRRK2 with LRRK2RCKW (Supplementary Figure S1, red rectangles), suggesting that crosstalk between the NtDs and CtDs is an important part of the signaling mechanism. Here, LRRK2 is linked to Parkinson disease.