Over 50% of these patients are diagnosed with ASD.[13, 14] This mutation is also found in ASD patients outside the PMS.[15, 16] Previous studies on Shank3 mutant mice revealed ASD‐like behaviors, such as impaired social interaction, anxiety‐like behavior, and reduced interest in novel objects.[17, 18] It is considered as one of the most promising mouse models of ASD to date.[16, 19, 20]. This evidence concerns the gene SHANK3 and Anxiety.