Behavioral studies revealed that nitrosative stress induces behavioral abnormalities in rodents.[81, 82] Similar to both the Shank3[17, 83, 84] and Cntnap2(‐/‐)[22, 25, 85] mouse models, WT mice treated with NO donor exhibited a reduced interest in novel objects, as well as impaired sociability and increased anxiety. This evidence concerns the gene SHANK3 and Anxiety.