SHANK3 and premenstrual tension: Shank3 is a scaffolding protein located in the postsynaptic density complex of excitatory synapses.[11] It binds to neuroligins and actin and participates in regulating actin polymerization, growth cone motility, dendritic spine morphology, and synaptic transmission.[12] Deletions or mutations in the SHANK3 gene have been found in patients with Phelan‐McDermid Syndrome (PMS).