The results showed that the incidence of total MACE and various MACE events (including malignant arrhythmia, heart failure, recurrent myocardial infarction, recurrent angina requiring revascularization, and cardiac mortality) were significantly lower in the group with serum irisin level greater than 69.07 ng/mL (Table 2; p < 0.001). The gene discussed is FNDC5; the disease is heart failure.