Even though CLEC2.Fc was unable to inhibit virus infection and replication (Fig 4D), CLEC2.Fc inhibited the expression of IL‐6, CXCL2, CXCL5, CCL2, and IP‐10 at day 3 and day 5 post‐infection, and the expression of TNF‐α, IFN‐γ, IL‐10, and CXCL1 was also suppressed at day 5 post‐infection (red columns, Fig 4E). This evidence concerns the gene TNF and viral infectious disease.