Moreover, administration of CLEC2.Fc fusion protein (comprising the extracellular domain of CLEC2 and Fc portion of human IgG1) attenuates TNF production and inflammatory macrophage accumulation in an LPS‐induced peritonitis model, suggesting blockade of CLEC2 and its endogenous ligand podoplanin is able to attenuate inflammation in vivo (Bourne et al, 2021). The gene discussed is CLEC1B; the disease is peritonitis.