In this study, two‐stage case–control studies showed that the SNP rs558814 affected the expression of lncRNA BCLET through regulation of transcriptional activity; BCLET altered the splicing pattern of MSANTD2 mRNA to promote the expression of MSANTD2‐004, which was involved in bladder carcinogenesis (Figure 5F). This evidence concerns the gene MSANTD2-AS1 and urogenital neoplasm.