SH3 and multiple ankyrin repeat domains‐containing SHANK family proteins (also known as ProSAP) have been reportedly associated with autism spectrum disorder (ASD) and SCZ.[7, 35] SHANK3 is a major postsynaptic scaffold protein that interacts with multiple proteins and complexes to orchestrate dendritic spines and modulate synaptic formation, maturation, and maintenance in excitatory neurons.[35b]SHANK3 deficiency in excitatory neurons disrupts the excitation/inhibition balance by affecting inhibitory synaptic transmission. Here, SHANK3 is linked to autism spectrum disorder.