PRDM16 plays a key role in brown remodeling in both BAT and WAT.[5, 6, 7, 8] Furthermore, PRDM16 is implicated in UCP1 and adipose browning‐independent processes, such as adipose fibrogenesis and sympathetic innervation.[10] Clinical studies have also shown that the amount of PRDM16 is associated with obesity and diabetes. Here, PRDM16 is linked to obesity due to melanocortin 4 receptor deficiency.