THBS1 and breast cancer: THBS1 is a member of the thrombospondin protein family.[43] It is involved in tissue remodeling and with implications for tumor formation, wound healing, and embryonic development.[44] THBS1 exerts different effects by binding to different cellular receptors.[45] Previous studies have shown that THBS1 is highly expressed in lymphoma,[46] breast cancer,[47] and oral squamous carcinoma,[48] promoting tumor cell adhesion, proliferation, apoptosis, invasion, and metastasis.