C3 and neoplasm: These include secreting proteases to degrade complement system factors,[9] utilizing surface proteins such as Gpd2 and Gpm1 to acquire human plasma proteins and complement regulators to the fungal surface to block complement activation,[9, 10] and secreting endogenous inhibitors to complex C3 and block further C3 cleavage by C3 convertase.[9b,d] Additionally, C. albicans can inhibit host immune responses by modulating macrophages in cases of tumor radiotherapy.[11]