In summary, Sap2‐273L infected mice displayed higher fungal load overall, less C3a release all the time, more exhausted CD4+ T cells, Treg cells and M2 macrophage induced, as well as less pro‐inflammatory cytokines released, but more IL‐10 and IL‐9 production at day 12 post‐infection (Figures S4f and S5, Supporting Information). Here, CD4 is linked to infection.