In addition, the authors found that low levels of ADAMTS13 correlated with coagulopathy, transfusion requirements and injury severity, suggesting that ADAMTS 13 repletion may be beneficial.16 Although ADAMTS13 is not typically associated with endothelial protective effects, Kleinveld et al.15 demonstrated in a mouse model of trauma-induced shock that recombinant ADAMTS13 reduced pulmonary endothelial permeability. The gene discussed is ADAMTS13; the disease is blood coagulation disease.