ADAMTS13 and thrombotic thrombocytopenic purpura: However, human ADAMTS13 has been shown to cleave mouse VWF in previous studies of trauma shock, traumatic brain injury, sepsis, and thrombotic thrombocytopenic purpura.33–36 We also used a significantly larger volume of LR compared with product which could have led to dilutional effects on the proteins of interest we studied.