In addition, the use of srGAP3 siRNA and CN04 promoted an increase in dendritic spine length and head diameter in rats with SNL, and promoted an increase in mushroom dendritic spine numbers, but had no significant effect on the total dendritic spine density or thin dendritic spine density, indicating that srGAP3 and Rac1 are mainly responsible for regulating the maturity of dendritic spines in the later stage of neuropathic pain. This evidence concerns the gene RAC1 and neuropathic pain.