More interestingly, Kim et al. recently showed that PRDM14-mediated transcriptional upregulation of CALM2 and SLC2A1 in colon cancers can rescue YAP suppression to sustain cell proliferation and survival [37], indicating the dominant roles of CALM2 and SLC2A1 in mediating YAP-associated cell proliferation and tumorigenesis. This evidence concerns the gene CALM2 and malignant colon neoplasm.