MMP9 and neoplasm: It can induce apoptosis of macrophages and inhibit tumor growth.401 Zoledronate, a third-generation nitrogen-containing bisphosphonate, has been shown to exhibit selective cytotoxicity towards MMP9-expressing TAMs and reduce the infiltration of TAMs, decrease tumor angiogenesis, and inhibit tumor progression.402 Similarly, BLZ-945 (a CSF-1R inhibitor) and chemotherapy drugs (such as doxorubicin and epirubicin) can specifically target and deplete TAMs.403 In addition, inhibiting macrophage recruitment is the second strategy for TAM-targeting strategy treatment.