Genetic deficiency of Piezo1 results in abrogation of these responses, which are triggered by a bacterial infection or LPS stimulation and involve the assembly of a complex between Piezo1 and TLR4 to remodel F-actin organization and enhance phagocytosis, mitochondrial-phagosomal ROS production, and bacterial clearance.160 The mechanically activated cation channel Piezo1 was investigated for its function in macrophage polarization and the detection of microenvironmental stiffness. This evidence concerns the gene PIEZO1 and bacterial infectious disease.