CCL2 and cancer: By releasing Arg-1, iNOS, oxygen radicals, or nitrogen species, TAMs may also suppress CD8+ T cell proliferation.295 To bring in Treg cells, TAMs release anti-inflammatory chemokines such as CCL2, CCL3, CCL4, CCL5, and CCL20.296 In addition, TAMs influence Tregs by producing CCL22 to decrease T cell-specific activity and encourage the development of cancer cells.297