PTP4A3 and osteosarcoma: CCL26 upregulation by phosphatase of regenerating liver-3 (PRL-3) promoted TAM infiltration, invasion, and metastasis in CRC.321 TAMs co-cultured with NSCLC cells produced conditioned media that promoted tumor cell invasion through EMT and B-Crystallin (CRYAB) overexpression, which induced lung cancer metastasis in vivo.322 According to Han’s results, TAMs promote osteosarcoma metastasis and invasion by increasing the production of COX-2, MMP9, and phosphorylated STAT3, which induces EMT.