Furthermore, c-Maf encourages IL-10 generation in macrophages while suppressing IL-12 output.221 c-Maf supports M2-like macrophage-mediated T-cell inhibition and tumor development by regulating numerous M2-related genes and their specific binding ability within a shared noncoding region of the Csf-1r gene.75 The gene discussed is MAF; the disease is neoplasm.