Nevertheless, extreme response of any polarization state can influence tumor formation, tissue necrosis, inflammation, and fibrosis.51 Anti-programmed death-ligand 1 (PD-L1) therapy in colorectal cancer (CRC) may be achieved by optimizing the release of sEV- microRNAs (miRNAs) from CRC and addressing PD-L1 in TAMs, according to recent research.52 In a breast cancer model, PYK2 controls TAMs. Here, CD274 is linked to colorectal cancer.