In contrast, substances that hinder M2 polarization, such as CSF1R inhibitors, corosolic acid, omeprazole, Gpr132 inhibitors, MEK/STAT3 inhibitors, fast-mimicking diets, and antibodies against IL-4, IL-4Rα, and IL-13, are also able to diminish the amount of tumor burden.372. The gene discussed is CSF1R; the disease is neoplasm.