Another research showed that the miR-3061/Sani1 axis might be the potential target of macrophage polarization and clarified that hyperglycemia enhanced sepsis-induced intestinal damage by boosting M1 macrophage polarization.302 NF-κB signaling was shown to be strongly connected with miR-22 in glioma TAMs, and the overexpression of miR-22 in macrophages was shown to suppress glioma growth in vivo. Here, NFKB1 is linked to central nervous system cancer.