Analyzed as OR (95% CI) per 1 SD for each of four IgM OSE, there were relatively consistent effects across age, sex, hypertension, and smoking status, and by triglyceride <150 versus ≥ 150 mg/dl, HDL-C <45 versus ≥ 45 mg/dl and LDL-C <130 versus ≥ 130 mg/dl thresholds, without evidence of effect modification (P interaction >0.05). The gene discussed is CD40LG; the disease is Hypertension.