In translational applications, to overcome excessive oxidative stress such as in diabetes mellitus or other clinical scenarios where natural IgM OSE are insufficient, exogenous administration of OSE-directed antibodies or overexpression by gene therapy approaches may be considered as has been shown in animal models (6, 10, 33, 34, 35, 36, 39, 40, 41, 42, 43, 44, 45). The gene discussed is CD40LG; the disease is diabetes mellitus.