Previous studies have reported that SFTSV glycoprotein binds to cell surface receptors such as DC-SIGN, NMMHC-IIA, and HS, then undergoes endocytosis through the action of calreticulin and clathrin to promote virus entry into cells; Gc is thus considered to be a key membrane fusion protein for SFTSV infection (Lozach et al., 2011; Sun et al., 2014; Halldorsson et al., 2016; Kim et al., 2019). Here, GC is linked to infection.