To date, the consensus is that AD etiology is expressed as a combination of genetic factors, amyloid β-protein (Aβ) accumulation, aberrant tau protein phosphorylation, neuroinflammation, oxidative stress, mitochondrial dysfunction, synaptic damage, and neuronal degeneration, which conspires in the onset and progression of the disease (1). The gene discussed is MAPT; the disease is Alzheimer disease.