By arresting tumor secreted-HMGB1, GL, Lf and Lf-GL reduced endothelial cell proliferation by 10.7 ± 2.9, 8.2 ± 2.9 and 13.0 ± 0.7%, respectively (Fig. 4c), and HMGB1 level decreased to 190.7 ± 19.0, 177.3 ± 3.6 and 176.1 ± 4.9 ng mL−1, respectively (Fig. 4d). This evidence concerns the gene HMGB1 and neoplasm.