Consistent with this interpretation, glutamine deprivation impaired cell viability, growth, and OXPHOS of SMARCA4/2-deficient ovarian and NSCLC cells much more potently than glucose depletion, while this was reversed in proficient controls (Fig. 3b–e, Supplementary Fig. 3a, b); glutamine deprivation also selectively induced strong apoptosis in SMARCA4/2-deficient cells (Supplementary Fig. 3c, d). This evidence concerns the gene SMARCA4 and non-small cell lung carcinoma.