SMARCA4 and cancer: In line with our above findings, glycolysis metabolites (glucose, lactate, 2- phosphoglyceric acid, 3-phosphoglyceric acid) were lower in SMARCA4/2-deficient cells compared to SMARCA4-restored cells, whereas glutamine and glutamate, amino acids that can sustain the TCA cycle once metabolized to α-ketoglutarate (α-KG)52, were more abundant in SMARCA4/2-deficient cells (Fig. 3a), suggesting that SMARCA4/2-deficient cancer cells are capable of switching to glutamine as their key fuel.