Validating the above findings, SMARCA4/2-deficient ovarian cancer cells, but not proficient controls including HGSOC and non-transformed ovarian or fallopian tube epithelial cells (IOSE120, IOSE386, FT190), were highly sensitive to IACS-010759, a selective inhibitor of electron transport chain Complex I39,40, in both viability (Fig. 1f) and growth (Fig. 1g) assays, accompanied with a strong apoptotic response (Fig. 1h, Supplementary Fig. 1c). This evidence concerns the gene SMARCA4 and ovarian carcinoma.