As mentioned above, the KCNQ4 mutations are associated with DFNA2.To explore whether in vivo gene editing is applicable to the treatment of DFNA2, a Kcnq4W276S/+ mouse model that exhibited progressive HL accompanied with outer hair cell degeneration was created and used as the mouse model of DFNA2 [184]. The gene discussed is KCNQ4; the disease is Hodgkins lymphoma.