The biomarkers ceramide (Cer) (16:0), phosphatidylcholine (PC) (32_0), oxidized cholesterol (7-ketocholesterol), lysophosphatidylcholine (LPC) (18:2), and cholesteryl ester (18:1) were found significantly associated with BNP, left ventricular ejection fractions, and HF risk [11, 15, 16]. The gene discussed is NPPB; the disease is hydrops fetalis.