Given that both of 22Rv1 and PC-3 are resistant to ENZ, whereas both LNCaP and C4-2B are sensitive to ENZ [5, 67, 74], we inferred that FL3 combined with ENZ may have a better effect on AR+ PCa cells, especially on C4-2B with the highest sensitivity to FL3. The gene discussed is AR; the disease is posterior cortical atrophy.