FL3, a synthetic derivative of flavaglines with higher tumor cell specificity and lower normal cell cytotoxicity compared to natural products, has presented potent tumor suppressive effect by targeting PHB1 in many cancers such as DLBCL, urothelial carcinoma of bladder (UCB), colorectal cancer (CRC), and glioblastoma cancer, etc. [23, 33–36]. Here, PHB1 is linked to neoplasm.