In the last decade, TCGA research network proposed molecular classification for endometrial cancer to four risk groups: polymerase epsilon exonuclease domain mutated (POLE EDM), mismatch repair deficient (MMRd), p53 wild-type/copy-number- low (p53 wt) and p53-mutated/copy number-high (p53 abn). The gene discussed is TP53; the disease is endometrial cancer.