Compared with those of the healthy controls, IL-10 and TGF-β1 concentrations increased significantly in the peripheral blood of the GC (IL-10: GC vs. HC; 4.28 ± 0.09 vs. 2.09 ± 0.15, P = 0.0006; TGF-β1: GC vs. HC; 28.51 ± 0.34 vs. 15.02 ± 0.31, P = 0.0008) and CRC patients (IL-10: CRC vs. HC; 4.01 ± 0.12 vs. 2.09 ± 0.15, P = 0.0008; TGF-β1: CRC vs. HC; 26.07 ± 0.29 vs. 15.02 ± 0.31, P = 0.0005) (Fig. 3A-B and Table 3). Here, IL10 is linked to colorectal carcinoma.