VEGFR activation by VEGF triggers MAPK/P38 signaling, which subsequently activates through tumor promoting factors and immunosuppressors (CD4high/CD8low/CD80high/NKG2Dlow/IL-2high/IL-6high/INF-ghigh) [17, 41, 44, 45] identified that MAPK/P38 are essential co-transcriptional activators in endothelial cells and MAPK/P38 activity is controlled by VEGF during developmental angiogenesis. This evidence concerns the gene VEGFA and neoplasm.