To verify whether overexpression of sAnk1.5 in skeletal muscle tissue might be involved in predisposing to T2D susceptibility, we generated transgenic mice (TgsAnk1.5/+) in which exogenous sAnk1.5 expression is under the transcriptional control of the muscle-specific rat myosin light chain (MLC) promoter36. Here, MLC1 is linked to type 2 diabetes mellitus.