This is possibly because tumor cells that most downregulated MCL-1 via inhibition of mTOR pathway (AZD8055) in combination with navitoclax have undergone apoptosis (high levels of cleaved PARP and cleaved caspase 3, Fig. 4e) resulting in removal of dead cells from the tumor by phagocytosis. This evidence concerns the gene CASP3 and neoplasm.