Moreover, GEO ameliorated liver inflammation in GAN diet-induced non-alcoholic steatohepatitis (NASH) mouse model via NLR family pyrin domain-containing 3 inflammasome (NLRP3)-mediated modulation of gut microbiota-lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) signaling pathways, and by increasing the abundance of beneficial microbes20. This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.