To examine the protective effect of GEO and citral against CVD and atherosclerosis, ApoE−/− mice were fed GAN diet + water supplemented with 1.3% ʟ-carnitine (GC) to induce atherosclerosis, and treated with GEO (Low: 50 mg/kg bw and High: 100 mg/kg bw) or citral (20 mg/kg bw) daily (Fig. 1a). This evidence concerns the gene APOE and atherosclerosis.