EIF2AK2 and viral infectious disease: Stress granules (SGs) are nonmembranous RNA–protein complexes composed of translationally stalled mRNAs, 40S ribosomes, eukaryotic initiation factors, and various RNA-binding proteins (e.g., Ras-GTPase-activating protein [SH3 domain] binding protein 1 [G3BP1], G3BP2, TIA1-related protein [TIAR], protein kinases (protein kinase R [PKR]), cell cycle–associated protein 1 (CAPRIN1), ubiquitin binding protein 2-like [UBAP2L]), which are formed in the cytoplasm in response to different cellular stresses, including virus infection (10).