Then, to investigate the reciprocal signaling axis back to tumor cells initiated by PSC activation, they performed TMT-based phosphoproteome comparison of KRASG12D and KRASWT PCCs treated with CM from SHH-stimulated PSCs, and the results revealed rapid activation of the IGF1R and AXL/TYRO3 signaling axes. The gene discussed is IGF1R; the disease is neoplasm.