Indeed, the upregulation of profibrotic proteins in LC and HCC patients that belong to the ECM (HSPG2, LUM, FBLN1, TNXB, TNC, and EFEMP1), inflammation (IL3, CXCL14, CCL21, BMP2, BMP4, OSM, and TIMP1), and angiogenesis (VWF, ANGPT1, protein C receptor [PROCR]) has been previously reported (61, 62, 63, 64). This evidence concerns the gene PROCR and laryngotracheoesophageal cleft.