For example, in cholesterol metabolism, the expression of LCAT and apolipoproteins (APOA1, APOA2, APOC1, APOC3, and APOB) that are involved in cholesterol metabolism continually decreased from HCs to LC patients and then increased in HCC patients (Fig. 3D). This evidence concerns the gene APOC1 and laryngotracheoesophageal cleft.