For example, in cholesterol metabolism, the expression of LCAT and apolipoproteins (APOA1, APOA2, APOC1, APOC3, and APOB) that are involved in cholesterol metabolism continually decreased from HCs to LC patients and then increased in HCC patients (Fig. 3D). Here, APOC3 is linked to laryngotracheoesophageal cleft.