A post-hoc analysis of a 26-week, phase 2 study in which T2D patients were randomized to receive tirzepatide, basal insulin or placebo, tirzepatide (especially at higher doses of 10 and 15 mg/week) reduced transaminases and non-invasive indices of hepatic fibrosis (including keratin-18 and procollagen III) [133]. Here, INS is linked to type 2 diabetes mellitus.