Nonetheless, we found 46 genes that carried either genomic or transcriptional alterations in all three resistant tumor groups, including 8 genes (Parp3, Gstm1, Il18, Padi4, Dnmt3b, Psrc1, Rif1, and Ankrd26) involved in DDR (Figures 4E and 4F). This evidence concerns the gene DNMT3B and neoplasm.